Variant Analytics of the Sars-Cov-2 Genome in South Karnataka Revealed Significance for Drug Resistance
Abstract
The SARS-CoV-2 virus is the vital cause of the pandemic. Combating COVID-19 requires a vaccine design to identify the basic variant patterns, i.e., point mutations and Single Nucleotide Polymorphism (SNPs). Identifying possible variants in the genome of SARS-CoV-2 from a global perspective is the basis for creating a database of Mut.-SNP.-SARS-CoV-2.This study involves selecting the data of the SARS-CoV-2 genome in south Karnataka. The variant analysis resulted in 19 novel variants contributing to the mechanism of drug resistance.
Downloads
References
Cui J, Li F, Shi ZL. (2019). Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol, 17: pp. 181–192.
Dong L, Tian J, He S, Zhu C, Wnag J, Liu C et al. (2020). Possible Vertical Transmission of SARS-CoV-2 from an Infected Mother to Her Newborn. JAMA, 323:1846-1848.
Dharma K, Khan S, Tiwari R, Sircar S, Bhat S, Malik YS et al. Coronavirus Disease 2019-COVID-19. Clin Microbiol Rev, 2020;33(4):e00028-20.
Furukawa NW, Brooks JT, Sobel J. (2020). Evidence Supporting Transmission (EST) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) while Presymptomatic or Asymptomatic. Emerg Infect Dis, 26:e201595.
Li Yen-Der, Chi Wei-Yu, Su Jun-Han, Ferrall Louise, Hung Chien-Fu, Wu T-C. (2020). Coronavirus vaccine development: From SARS and MERS to COVID-19. J Biomed Sci, 27:104.
Petrakis D, Margină D, Tsarouhas K, Teckos F, Stan M, Nikitovic D et al. Obesity is a risk factor for increased COVID-19 prevalence, severity and lethality (Review). Mol Med Rep, 2020; 22(1):9-19.
Vijaykrishna D, Smith GJ, Zhang JX, Peiris JS, Chen H, Guan Y. (2007). Evolutionary insights into the ecology of coronaviruses. Journal of Virology, 81: pp. 4012–4020.
Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L et al. (2021). "Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England". Nature, 593: 266-269.
Weiss SR, Navas-Martin S. (2005). Coronavirus pathogenesis (Cp) and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev, 69:635-664.