Mannich Reaction Catalyzed by L-Cysteine-Decorated ZnS Nanoparticles for P-amino Carbonyl Compound Synthesis

Abstract

One-pot three-component Mannich reactions of ketone, aromatic aldehyde and aromatic amines were efficiently catalyzed by recyclable heterogeneous L-Cysteine supported on ZnS nanoparticles at the ambient temperature to give various p—amino carbonyl compounds with high yields. This simple method has some advantages such as mild condition and no environmental pollution. Structures of the compounds were confirmed by ¹H NMR and IR spectral analyses. ZnS nanoparticles were prepared in hydrothermal procedure from an aqueous solution of Zinc acetate and NaS in the presence of L-Cysteine. L-Cysteine supported on ZnS nanoparticles was characterized by FT-IR, TEM, TGA/DTA and XRD analysis.